Kisii School emerged the best school in the KCSE 2021/2022 exams in the County with a mean score of 8.93 which is a B(plain).
2021/2022 BEST, TOP PERFORMING SCHOOLS IN KISII COUNTY
| Pos Nationally | School Name | Mean Score | County | |
| 34 | Kisii School | 8.93 | B | Kisii |
| 35 | Kiage Tumaini | 8.93 | B | Kisii |
| 41 | Nyabururu Girls High School | 8.84 | B | Kisii |
| 51 | Riokindo Boys | 8.6 | B | Kisii |
| 62 | Nyakoiba Secondary | 8.41 | B- | Kisii |
| 88 | Nyaikuro High School | 8.046 | B- | Kisii |
| 120 | Cardinal Otunga | 7.44 | C+ | Kisii |
| 128 | Kereri Girls | 7.3 | C+ | Kisii |
| 134 | Riokindo Girls | 7.2 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |
| 150 | St Charles Lwanga Ichuni | 6.63 | C+ | Kisii |