Maseno School emerged the best school in the KCSE 2021/2022 exams in the County with a mean score of 9.022 which is a B (plain).
2021/2022 BEST, TOP PERFORMING SCHOOLS IN KISII COUNTY
| Pos Nationally | School Name | Mean Score | County | |
| 29 | Maseno School | 9.022 | B | Kisumu |
| 64 | Chemelil Sugar Academy | 8.4 | B- | Kisumu |
| 71 | Sigoti Complex Secondary School | 8.29 | B- | Kisumu |
| 80 | Kisumu Girls High School | 8.15 | B- | Kisumu |
| 119 | Nyabondo Boys High School | 7.5 | B- | kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |
| 141 | Kisumu School | 6.9667 | C+ | Kisumu |